SupplySide Global
JBSL-USA to Showcase NSK-SD Nattokinase at SupplySide West
The enzyme, found naturally in natto, is evidenced to support several measures of cardiovascular health.
By: Mike Montemarano
Associate Editor, Nutraceuticals World
Booth 3842
JBSL-USA will be showcasing NSK-SD, its nattokinase enzyme ingredient formulated for cardiovascular support, at SupplySide West.
Nattokinase, a serine protease enzyme with 275 amino acid residues, is naturally present in natto, a traditional Japanese dish of fermented soybeans. NSK-SD nattokinase is a patented enzyme produced from non-GMO soybeans fermented from a proprietary strain of Bacillus subtilis natto. All naturally-occurring vitamin K2 is removed from the ingredient, as K2 may interfere with warfarin and may increase blood coagulation, according to the company.
JBSL pioneered the nattokinase category with emerging findings in in vitro and in vivo human studies. NSK-SD is the only nattokinase that has its own published safety, efficacy, and identity data, JBSL reports. JBSL developed a testing method called I-BOX to identify its ingredient as nattokinase, while ruling out different enzymes.
“NSK-SD, featuring the tagline of ‘The Science of Nattokinase,’ has over 55 clinical studies, including 23 human clinical trials exploring its efficacy in several areas,” said Vincent Hackel, chief executive officer of Guzen, the U.S. distributor of NSK-SD.
Clinical studies over the past 26 years support health claims related to:
- Overall cardiovascular health
- Arterial health with strong fibrinolytic activity
- Promotion of normal blood pressure
- Promotion of whole blood viscosity
- Increased blood circulation
- Normal platelet aggregation
- Managing C-reactive protein
One of the most significant factors of concern about heart health is high diastolic and systolic blood pressure. In six human studies, participants with varied blood pressure parameters such as hypertension, risk of hypertension, high blood pressure, and uncontrolled systolic hypertension saw reduced systolic and diastolic readings after supplementing with NSK-SD.
NSK-SD is a white, odorless, tasteless, water-soluble, free-flowing powder ideal for a diverse range of supplements, and is non-GMO, vegetarian, non-irradiated, is self-affirmed GRAS, and is recognized by both the Japan Health and Nutrition Food Authorization (JHFA) and Japan Nattokinase Association as authentic nattokinase. It is the only nattokinase approved by the European Food Safety Authority (EFSA) and Health Canada.


